کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2113588 1084479 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65 – a novel Wnt/β-catenin signaling inhibitor
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65 – a novel Wnt/β-catenin signaling inhibitor
چکیده انگلیسی

We investigated the effect of a novel Wnt/β-catenin signaling inhibitor, AV65 on imatinib mesylate (IM)-sensitive and -resistant human chronic myeloid leukemia (CML) cells in vitro. AV65 inhibited the proliferation of various CML cell lines including T315I mutation-harboring cells. AV65 reduced the expression of β-catenin in CML cells, resulting in the induction of apoptosis. Moreover, AV65 inhibited the proliferation of hypoxia-adapted primitive CML cells that overexpress β-catenin. The combination of AV65 with IM had a synergistic inhibitory effect on the proliferation of CML cells. These findings suggest that AV65 could be a novel therapeutic agent for the treatment of CML.


► AV65 is a novel Wnt/β-catenin signaling inhibitor.
► AV65 inhibited the proliferation of CML cell including T315I-mutated cells.
► AV65 also inhibited the proliferation of hypoxia-adapted primitive CML cells.
► AV65 inhibited the CML cell proliferation in combination with imatinib.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 312, Issue 1, 15 December 2011, Pages 91–100
نویسندگان
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