کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2113599 | 1546695 | 2011 | 8 صفحه PDF | دانلود رایگان |
P300 impacts the transcription of several genes involved in biological behavior of human malignancies including hepatocellular carcinomas (HCC). We found p300 is highly expressed in 47% of surgically resected HCC specimens by immunohistochemistry, which correlated with advanced TNM staging (P = 0.034), vascular invasion (P = 0.036), intrahepatic metastasis (P = 0.001) and shortened overall survival (P = 0.028). In vitro study, knocking down of p300 expression in hepatoma cells recovered E-cadherin expression, inhibited the translocation of beta (β)-catenin into the nuclei, decreased cyclin D1 activity and suppressed the migration/invasion of HCC cells. Furthermore, suppression of p300 led to down-regulation of epithelial-mesenchymal transition (EMT)-related molecules such as Snail, Twist and HIF-1 alpha. These observations suggest that p300 contributes to the EMT-related progression of HCCs.
► P300 is highly expressed in 47% of surgically resected HCC specimens by immunohistochemistry.
► High expression of p300 in HCCs is a predictor of shortened overall survival.
► Overexpressed-p300 may promote EMT-like phenotypic change, particularly, in p53 mutated HCC cells.
Journal: Cancer Letters - Volume 310, Issue 2, 28 November 2011, Pages 140–147