کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113680 | 1084487 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epstein-Barr virus and breast cancer: Serological study in a high-incidence area of nasopharyngeal carcinoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Epstein-Barr virus and breast cancer: Serological study in a high-incidence area of nasopharyngeal carcinoma Epstein-Barr virus and breast cancer: Serological study in a high-incidence area of nasopharyngeal carcinoma](/preview/png/2113680.png)
چکیده انگلیسی
We investigated IgA and IgG levels against EBV viral capsid antigen (VCA) and nuclear antigen-1 (EBNA-1) in serum of 223 women with breast cancer (BC) and 309 controls in Guangzhou, China. VCA IgA levels were significantly associated with an elevated risk of BC, with adjusted ORs (95%CIs) of 1.70 (1.05–2.76) (seropositivity) and 2.21 (1.11–4.40) (unit increases in OD value). This association was stronger among young, lean, and HER2+ women. The EBNA-1 IgA levels in OD value, but not seropositivity, were associated with an increased risk of BC among ER+, PR+, and HER2+ patients. None of the IgG variables was related to BC. These results suggest the EBV association with BC in an endemic area of nasopharyngeal carcinoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 309, Issue 2, 28 October 2011, Pages 128–136
Journal: Cancer Letters - Volume 309, Issue 2, 28 October 2011, Pages 128–136
نویسندگان
Jian-Rong He, Lu-Ying Tang, Dan-Dan Yu, Feng-Xi Su, Er-Wei Song, Ying Lin, Shen-Ming Wang, Guan-Chao Lai, Wei-Qing Chen, Ze-Fang Ren,