کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2113934 | 1084507 | 2010 | 6 صفحه PDF | دانلود رایگان |
Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Pyruvate is the starting substrate for the tricarboxylic acid (TCA) cycle and plays a central role in intermediary metabolism. The present study was to determine whether ethyl pyruvate affects the expression of hypoxia-inducible factor 1 alpha (HIF-1α) and to explore the mechanism of HIF-1α regulation. We found that ethyl pyruvate increased HIF-1α stability via inhibition of pVHL-mediated degradation. Furthermore, ethyl pyruvate enhanced the reactive oxygen species (ROS) generated through the TCA cycle in mitochondria. Taken together, our results support a novel role for ethyl pyruvate in HIF-1α stabilization by which high rates of the TCA cycle can promote ROS production.
Journal: Cancer Letters - Volume 295, Issue 2, 28 September 2010, Pages 236–241