کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113996 | 1084511 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-κB that physically associated to previously uncharacterized κB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased (p = 0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 292, Issue 2, 28 June 2010, Pages 176–185
Journal: Cancer Letters - Volume 292, Issue 2, 28 June 2010, Pages 176–185
نویسندگان
Helen H.L. Chiu, Theresa M.K. Yong, Jun Wang, Yuwei Wang, Robert L. Vessella, Takeshi Ueda, Yu-Zhuo Wang, Marianne D. Sadar,