کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114065 1084515 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cancer stem cells sustaining the growth of mouse melanoma are not rare
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Cancer stem cells sustaining the growth of mouse melanoma are not rare
چکیده انگلیسی

Cancer stem cell (CSC) is generally believed to be a very small proportion of tumor cells capable of initiating and sustaining growth of the tumor. Its existence is usually demonstrated by xenotransplanting human cancer cells in immunodeficient mice. In this paper, we report that the growth of B16-F10 melanoma cells in syngeneic mice could be maintained by a relatively larger proportion (>10%) of tumor cells. The result of this study does not seem to support the current view that cancer stem cells (CSCs) responsible for the sustainable growth of tumor are rare.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 292, Issue 1, 1 June 2010, Pages 17–23
نویسندگان
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