کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114239 1084525 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement upregulation in photodynamic therapy-treated tumors: Role of Toll-like receptor pathway and NFκB
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Complement upregulation in photodynamic therapy-treated tumors: Role of Toll-like receptor pathway and NFκB
چکیده انگلیسی

Recent investigations have established that complement activation is induced following treatment of solid tumors by photodynamic therapy (PDT). The present study using mouse SCCVII tumor model affirms the proficiency of tumor-associated macrophages (TAMs) to produce complement proteins upon receiving signals such as Hsp70 released from PDT-treated cancer cells. Such communication is shown to trigger signaling involving Toll-like receptors (TLR) 2 and 4 and the activation of transcription factor NFκB leading to complement protein production. This example of complement system regulation by TLRs adds to a growing awareness of cross-talk within these two key components of innate immunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 281, Issue 2, 28 August 2009, Pages 232–238
نویسندگان
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