کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114269 | 1084527 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers](/preview/png/2114269.png)
چکیده انگلیسی
Cancer stem cells are known for their inherent resistance to therapy. Here we investigated whether normal stem cells with acquired resistance to stress can be used to identify novel markers of cancer stem cells. For this, we generated a human embryonic stem cell line resistant to Trichostatin A and analyzed changes in its gene expression. The resistant cells over-expressed various genes associated with tumor aggressiveness, many of which are also expressed in the CD133+ glioma cancer stem cells. These findings suggest that stress-resistant stem cells generated in vitro may be useful for the discovery of novel markers of cancer stem cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 289, Issue 2, 28 March 2010, Pages 208–216
Journal: Cancer Letters - Volume 289, Issue 2, 28 March 2010, Pages 208–216
نویسندگان
Shaker A. Mousa, Thangirala Sudha, Evgeny Dyskin, Usawadee Dier, Christine Gallati, Christine Hanko, Sridar V. Chittur, Abdelhadi Rebbaa,