کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114478 | 1084540 | 2009 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Marchantin C, a novel microtubule inhibitor from liverwort with anti-tumor activity both in vivo and in vitro Marchantin C, a novel microtubule inhibitor from liverwort with anti-tumor activity both in vivo and in vitro](/preview/png/2114478.png)
Microtubules are long-standing targets in cancer chemotherapy. Previously, we reported that marchantin C triggers apoptosis of human tumor cells. We show here that marchantin C induced cell cycle arrest at G2/M phase in A172 and HeLa cells. In addition, marchantin C decreased the quantity of microtubules in a time- and dose-dependent manner in these cells. Exposure of purified bovine brain tubulin to marchantin C inhibited polymerization of gross tubulin in vitro. Moreover, marchantin C potently suppressed the growth of human cervical carcinoma xenografts in nude mice. Marchantin C-treated xenografts showed decreased microtubules, Bcl-2 and increased cyclin B1, Bax, caspase-3, indicating that marchantin C possess the same ability to induce microtubules depolymerization and tumor cell apoptosis in tumor-bearing mice as in vitro. In conclusion, marchantin C is a novel microtubule inhibitor that induces mitotic arrest of tumor cells and suppresses tumor cell growth, exhibiting promising antitumor therapeutic potential.
Journal: Cancer Letters - Volume 276, Issue 2, 18 April 2009, Pages 160–170