کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114506 1084541 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis
چکیده انگلیسی

Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 278, Issue 1, 8 June 2009, Pages 113–121
نویسندگان
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