کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114516 | 1084542 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nasopharyngeal carcinoma (NPC) is a common malignancy in southern China and Southeast Asia. Nuclear factor-κB (NF-κB)-activation plays critical roles in Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) mediated tumorigenesis in NPC. A functional insertion/deletion polymorphism (−94 insertion/deletion ATTG) in the promoter of NFKB1 gene, which encodes the p50 subunit of NF-κB protein complex, was recently identified. This study found that the frequency of ATTG2 allele in NPC patients was significantly higher than that in control subjects (66% vs. 57.1%, p = 0.015, OR = 1.453), suggesting that the functional NFKB1 promoter polymorphism is associated with increased risk for NPC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 275, Issue 1, 8 March 2009, Pages 72–76
Journal: Cancer Letters - Volume 275, Issue 1, 8 March 2009, Pages 72–76
نویسندگان
Bin Zhou, Li Rao, Yi Li, Linbo Gao, Yanyun Wang, Yu Chen, Hui Xue, Yaping Song, Ying Peng, Miao Liao, Lin Zhang,