کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114659 1084549 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of NF-κB in fusogenic membrane glycoprotein causing HL-60 cell death: Implications for acute myeloid leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Inhibition of NF-κB in fusogenic membrane glycoprotein causing HL-60 cell death: Implications for acute myeloid leukemia
چکیده انگلیسی

Viral fusogenic membrane glycoproteins (FMGs) are new therapeutic genes for the control of tumor growth, the cellular mechanisms mediating cell death is non-apoptotic. However, the precise molecular mechanism remains to be elucidated. Here, we showed overexpression of HSP70 in HL-60 cells mediated by Gibbon Ape leukemia virus hyperfusogenic envelope protein (GALV-FMG) inhibited the nuclear translocation of p65, the transcriptive activity of NF-κB and prevented the degradation of IκB. NF-κB may negatively regulate HSP70 expression, which made a positive feed back loop for expression of HSP70. FMG expression in HL-60 cells leaded to the formation of multinucleated syncytia and cell death, the main death mode of cells is necrosis. This form of cell death should be effective in vivo, gene therapy basing on FMG deserve further study for the treatment of AML.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 273, Issue 1, 8 January 2009, Pages 114–121
نویسندگان
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