کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114751 1084554 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The human homolog of fission yeast Rad17 is implicated in tumor growth
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The human homolog of fission yeast Rad17 is implicated in tumor growth
چکیده انگلیسی
The Schizosaccharomyces pombe rad17 is a checkpoint protein critical for maintenance of genomic stability. Since the loss of checkpoint control is a common feature of tumor cells, we investigated the biological function of the human homolog hRAD17. Expression of hRAD17 in a fission yeast rad17 deleted strain reduced growth of yeast colonies and caused slower progression through cell cycle. Immunoprecipitated hRad17 exhibited exonuclease activity. hRAD17 delayed growth of NIH3T3 fibroblasts transformed by the H-ras oncogene in nude mice. Our results support that hRAD17, similarly to other human genes involved in checkpoint mechanisms, plays a role in control of tumor growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 266, Issue 2, 8 August 2008, Pages 194-202
نویسندگان
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