کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114796 1084556 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Melatonin down-regulates hTERT expression induced by either natural estrogens (17β-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Melatonin down-regulates hTERT expression induced by either natural estrogens (17β-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells
چکیده انگلیسی

The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17β-estradiol (E2) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E2 or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E2- and Cd-mediated hTERT transactivation triggered by ERα in transfected HeLa cells, (c) Mel inhibits hTERT expression induced by E2 or Cd in MCF-7 cells. Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors or carcinogenesis by environmental or occupational exposure to xenoestrogens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 268, Issue 2, 18 September 2008, Pages 272–277
نویسندگان
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