کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114871 1084560 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypoxia in microscopic tumors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Hypoxia in microscopic tumors
چکیده انگلیسی

Tumor hypoxia has been commonly observed in a broad spectrum of primary solid malignancies. Hypoxia is associated with tumor progression, increased aggressiveness, enhanced metastatic potential and poor prognosis. Hypoxic tumor cells are resistant to radiotherapy and some forms of chemotherapy. Using an animal model, we recently showed that microscopic tumors less than 1 mm diameter were severely hypoxic. In this review, models and techniques for the study of hypoxia in microscopic tumors are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 264, Issue 2, 18 June 2008, Pages 172–180
نویسندگان
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