کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114949 1084565 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck
چکیده انگلیسی

The transcription factor p63 is commonly over-expressed in squamous cell carcinomas of the head and neck (SCCHN). By microarray analysis of p63-siRNA-treated SCCHN cells we identified 127 genes whose expression relies on over-expression of p63. More than 20% of these genes are involved in cell motility. Chromatin immunoprecipitation and reporter assay revealed PAI-1 and AQP3 as direct p63 transcriptional targets. In addition to PAI-1, most of the key cell motility-related molecules are up-regulated by p63, such as MMP14 and LGALS1. Our findings indicate a contribution by p63 in cell invasion and migration, supporting an oncogenic role for p63 in SCCHN.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 263, Issue 1, 8 May 2008, Pages 26–34
نویسندگان
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