کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2115058 | 1084570 | 2008 | 9 صفحه PDF | دانلود رایگان |
Green tea catechins have recently gained significant acceptance as a cancer preventive, and one of the important features of catechins is their interactions with various target molecules. We recently found a functional and structural similarity between catechins and chaperones: Stochastic conformational analysis in silico revealed numerous conformations of (−)-epigallocatechin gallate, (−)-epicatechin gallate and (−)-epigallocatechin, showing a unique flexibility and mobility of the catechin molecules and suggesting the significance of a galloyl group in conformational variation. Since these conformations result in interaction with various types of molecules, we think that green tea catechin induces cancer preventive activity mediated through a chaperone-like property.
Journal: Cancer Letters - Volume 261, Issue 1, 8 March 2008, Pages 12–20