کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115105 1084575 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma
چکیده انگلیسی

In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrated higher chromosomal instability rates in tumor samples (average: 56.86%, range: 36.24–76.78%) than in controls (average: 11.54%, range: 9.91–14.84%) (P < 0.0001). As well as intrachromosomal instability rates were elevated in tumor (average: 18.45% range: 8.34–35.8%) as compared with controls (average: 4.18% range: 3.47–4.81%) (P < 0.0001). An increase in BUB1B and MAD2L1 transcripts was demonstrated in the majority of the tumor tested. BUB1B mRNA levels but not MAD2L1 levels correlated with intrachromosomal instability (r = 0.722, P = 0.018).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 254, Issue 2, 8 September 2007, Pages 298–307
نویسندگان
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