کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115371 1084591 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High throughput proteomic strategies for identifying tumour-associated antigens
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
High throughput proteomic strategies for identifying tumour-associated antigens
چکیده انگلیسی

Tumours elicit an immune response in the host organism and this area has been studied for decades. Initially, tumour-associated antigens were studied by examining a few proteins at a time using techniques such as 1-D SDS–PAGE and sandwich ELISAs. Now, however, with the development of high-throughput strategies, multiple potential antigens in a single experiment could be uncovered. The prevailing view is that these antigens can be used as biosensors for cancers. In addition, some of these antigens may indeed be used as targets for immunotherapy. SEREX, SERPA, and protein microarray technology have been the three dominant strategies employed to identify tumour-associated antigens. In this mini-review, we aim to describe these three techniques and provide their advantages and disadvantages. In addition, we aim to address some of the challenges of cancer immunomics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 249, Issue 1, 28 April 2007, Pages 110–119
نویسندگان
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