کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115481 1084596 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selective radiosensitization by nitric oxide in tumor cell lines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Selective radiosensitization by nitric oxide in tumor cell lines
چکیده انگلیسی

The radiosensitizing effect of nitric oxide (NO) on mouse and human tumor cells with different degrees of malignancy was evaluated. Cells pre-treated with the NO donor diethylenetriamine-NO (DETA-NO), were irradiated with γ rays. Survival curves were obtained by clonogenicity and fitted to the linear–quadratic model. Results demonstrated an association between radiosensitization and degree of malignancy. The more malignant the cell line, the higher the degree of radiosensitization by DETA-NO. In conclusion, the differential radiosensitizing effect of DETA-NO shown here is of great interest for the potential use of NO in radiotherapy, due to an enhanced radiation effect on tumor vs. normal tissue.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 248, Issue 1, 8 April 2007, Pages 123–130
نویسندگان
, , , , ,