کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115515 1084598 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines
چکیده انگلیسی

Four of the six genes constituting the mouse Pulmonary adenoma susceptibility 1 (Pas1) locus haplotype carry amino acid variants: Lrmp, Casc1, Ghiso, and Lmna-rs1. In vitro colony formation assay of human lung cancer cell lines A549 and NCI-H520 transfected with the allelic variants of the four genes revealed allele-specific modulations of colony numbers by Lmna-rs1 and Casc1, but not by Lrmp or Ghiso. In A549 and NCI-H520 cells, the A/J allele of Lmna-rs1 produced ∼4- and ∼2-fold, respectively, more transfectants than did the C57BL/6J allele, whereas the A/J allele of Casc1 produced ∼6- and ∼5-fold fewer transfectants, respectively, as compared to the C57BL/6J allele. Inhibition of clonogenicity by allelic forms of Pas1 candidate genes was not mediated by induction of apoptosis. These findings provide evidence that allelic variants of mouse Pas1 candidate genes differentially modulate growth of human cancer cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 244, Issue 2, 8 December 2006, Pages 176–181
نویسندگان
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