کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115574 1546702 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer
چکیده انگلیسی

The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20–5.06; P=0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR=3.40 95% CI 1.61–7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 246, Issues 1–2, 8 February 2007, Pages 324–330
نویسندگان
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