کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115579 1084600 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sprouty and cancer: The first terms report
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Sprouty and cancer: The first terms report
چکیده انگلیسی

The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 242, Issue 2, 28 October 2006, Pages 141–150
نویسندگان
, , , , , , ,