کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115584 1084600 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bifunctional effect of resveratrol on the expression of ErbB2 in human breast cancer cell
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Bifunctional effect of resveratrol on the expression of ErbB2 in human breast cancer cell
چکیده انگلیسی

This study evaluated the effect of resveratrol on the expression of ErbB2 in a human breast cancer cell line, MCF-7. Low concentrations of resveratrol (1–10 μM) reduced the basal expression level of ErbB2 in MCF-7 cells cultured in an estrogen-free medium. When cells were cultured in a medium containing estrogen, resveratrol increased the ErbB2 protein levels in a dose-dependent manner. Resveratrol increased the luciferase reporter gene activity in cells transfected with the −756 bp flanking region of the human erbB2 gene. Resveratrol increased the nuclear levels of AP-2α and AP-2γ, and the induction of the luciferase reporter gene by resveratrol was inhibited by a mutation of two AP-2 binding sites in the promoter region of the human erbB2 gene. Blocking the ERK, p38 kinase or PI3-kinase activity had no effect on the resveratrol-inducible transactivation of the erbB2 gene and the ErbB2 expression level.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 242, Issue 2, 28 October 2006, Pages 198–206
نویسندگان
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