کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115738 | 1084608 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prognostic impact of p53 protein overexpression in patients with node-negative lung adenocarcinoma
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Prognostic impact of p53 protein overexpression in patients with node-negative lung adenocarcinoma Prognostic impact of p53 protein overexpression in patients with node-negative lung adenocarcinoma](/preview/png/2115738.png)
چکیده انگلیسی
Prognostic value of p53 protein expression in node-negative lung adenocarcinoma is still controversy. The expression of p53 protein was examined immunohistochemically in lung adenocarcinoma using monoclonal antibody BP53-12. A total 131 cases of primary lung adenocarcinoma were examined. Relationship between expression of p53 protein and clinicopathologic factors were studied. Overexpression of p53 protein was found in 19 patients (14.5%). Univariate and multivariate analysis showed that overexpression of p53 protein was an independent prognostic factor in node-negative lung adenocarcinoma. p53 alteration could be a valuable predictor for prognosis in node-negative lung adenocarcinoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 237, Issue 2, 18 June 2006, Pages 242–247
Journal: Cancer Letters - Volume 237, Issue 2, 18 June 2006, Pages 242–247
نویسندگان
Hiroyuki Suzuki, Takanori Kawaguchi, Takeo Hasegawa, Atsushi Yonechi, Jun Ohsugi, Mitsunori Higuchi, Fumihiko Yamada, Yutaka Shio, Koichi Fujiu, Ryuzo Kanno, Akio Ohishi, Mitsukazu Gotoh,