کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115847 | 1084613 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in rats](/preview/png/2115847.png)
In order to assess whether light exposure at night influences the growth of mammary tumors, as well as the role of melatonin in this process, female rats bearing DMBA-induced mammary adenocarcinomas were exposed to different lighting environments. Animals exposed to light-at-night, especially those under a constant dim light during the darkness phase, showed: (a) significantly higher rates of tumor growth as well as lower survival than controls, (b) higher concentration of serum estradiol, and (c) lower nocturnal excretion of 6-sulfatoxymelatonin, without there being differences between nocturnal and diurnal levels. These results suggest that circadian and endocrine disruption induced by light pollution, could induce the growth of mammary tumors.
Journal: Cancer Letters - Volume 235, Issue 2, 28 April 2006, Pages 266–271