کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115898 1084615 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea
چکیده انگلیسی

Leptin plays an important role in the regulation of body fat homeostasis, and potential associations of leptin receptor gene (LEPR) polymorphisms with obesity have been suggested. Obesity is considered to relate to breast cancer. We assessed the role of leptin in relation to breast cancer. We measured the serum leptin concentrations of 45 Korean pre-treatment patients with breast cancer and 45 age-matched controls. By direct sequencing, we investigated four leptin receptor gene (LEPR) polymorphisms at codons 109, 223, 656, and 1019. There was no significant difference between the mean leptin concentrations of the patient and control groups in both pre- and post-menopausal women. The frequencies of the wild-type for LEPR codons 109, 223, and 1019 were very low. No increased risk estimate was found for the four LEPR polymorphisms. Our results indicate that it is difficult to explain breast cancer on the basis of serum leptin concentrations or polymorphisms in the LEPR gene.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 237, Issue 1, 8 June 2006, Pages 137–142
نویسندگان
, , , , ,