کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115956 1084618 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma
چکیده انگلیسی
The gene for insulin-like growth factor two, IGF2 is maternally imprinted. Fifteen heterozygous samples were analyzed for the IGF2 imprinting status and promoter usage. IGF2 LOI was detected in four non-tumorous tissues and in six laryngeal squamous cell carcinoma (LSCC) tumors. There was no clear pattern of specific promoter activity in LSCC tumors and the adjacent normal tissues. P1 promoter usage was active in eight LSCCs, among them four with LOI. As it was activated in four tumors with maintenance of imprinting (MOI) and four non-tumors, we concluded that P1 promoter is not exclusively connected with IGF2 LOI in LSCC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 238, Issue 2, 18 July 2006, Pages 224-229
نویسندگان
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