کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115980 1084620 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid induction of malignant tumor in Sprague–Dawley rats by injection of RK3E-ras cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Rapid induction of malignant tumor in Sprague–Dawley rats by injection of RK3E-ras cells
چکیده انگلیسی

Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague–Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 235, Issue 1, 8 April 2006, Pages 53–59
نویسندگان
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