کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116011 | 1084621 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
BARD1 is a crucial partner of the breast and ovarian tumor suppressor BRCA1 required for ubiquitin ligase activity and for reciprocal stabilization in cells. We report here an alternatively spliced human BARD1 mRNA variant (BARD1ΔRIN) isolated from a HeLa cell cDNA library. It is characterized by deletion of exons 2–6 that encode most of the RING finger domain and the entire span of ankyrin repeats. ΔRIN transcript was detected in all breast cancer-cell lines studied although its protein expression level was low. ΔRIN does not interact with BRCA1, whereas it interacts with and colocalizes with CstF-50 to cytoplasmic dots. Hence, a deletion variant of BARD1 occurs in cells and may play a distinct role with CstF-50.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 233, Issue 1, 20 February 2006, Pages 108–116
Journal: Cancer Letters - Volume 233, Issue 1, 20 February 2006, Pages 108–116
نویسندگان
Makiko Tsuzuki, Wenwen Wu, Hiroyuki Nishikawa, Ryosuke Hayami, Daisuke Oyake, Yukari Yabuki, Mamoru Fukuda, Tomohiko Ohta,