کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2116065 1084623 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Impact of p53 aberration on the progression of Adult T-cell Leukemia/Lymphoma
چکیده انگلیسی

Based on statistical analysis of its age-dependent occurrence, a multi-step carcinogenesis model has been proposed for Adult T-cell Leukemia/Lymphoma (ATLL). We have previously reported that the deletion of the p16 gene is a key event in ATLL progression. In the current study, we report for the first time that the aberrations of p16 and p53 are mutually exclusive in ATLL and either of the two events is sufficient for the ATLL progression. More than half of the patients had one of the two aberrations, and both aberrations emerged as significant markers for a poor prognosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 234, Issue 2, 28 March 2006, Pages 249–255
نویسندگان
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