کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116301 | 1084825 | 2013 | 11 صفحه PDF | دانلود رایگان |

Multidrug resistance (MDR) and drug toxicity are two major factors responsible for the failure of cancer chemotherapy. Herein the efficacy and safety of combination therapy using doxorubicin (Dox, D)–mitomycin C (MMC, M) co-loaded stealth polymer-lipid hybrid nanoparticles (DMsPLNs) were evaluated in sensitive and MDR human mammary tumor xenografts. DMsPLN demonstrated enhanced efficacy compared to liposomal Dox (PLD) with up to a 3-fold increase in animal life span, a 10–20% tumor cure rate, undetectable normal tissue toxicity and decreased tumor angiogenesis. These results suggest DMsPLN have potential as an effective treatment of breast cancer.
• Therapeutic efficacy and toxicity of doxorubicin-mitomycin C co-loaded nanoparticles (DMsPLN) were determined.
• DMsPLN exhibited enhanced anti-cancer efficacy in both sensitive and multidrug resistant orthotopic breast tumor xenografts.
• DMsPLN treatment inhibited tumor angiogenesis.
• DMsPLN treatment did not result in any systemic or acute toxicity.
Journal: Cancer Letters - Volume 334, Issue 2, 1 July 2013, Pages 263–273