کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116347 | 1084849 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo](/preview/png/2116347.png)
چکیده انگلیسی
Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derived exosomes (MSC-exosomes) on tumor growth in vitro and in vivo. Our results showed that MSC-exosomes promoted tumor growth in vivo. MSC-exosomes enhanced vascular endothelial growth factor (VEGF) expression in tumor cells by activating extracellular signal-regulated kinase1/2 (ERK1/2) pathway. Inhibition of ERK1/2 activation reserved the increase of VEGF level by MSC-exosomes. Our findings demonstrate a new mechanism through which MSC-exosome-mediated cell–cell interactions may contribute to tumor progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 315, Issue 1, 1 February 2012, Pages 28–37
Journal: Cancer Letters - Volume 315, Issue 1, 1 February 2012, Pages 28–37
نویسندگان
Wei Zhu, Ling Huang, Yahong Li, Xu Zhang, Jianmei Gu, Yongmin Yan, Xiaomeng Xu, Mei Wang, Hui Qian, Wenrong Xu,