کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116405 | 1084881 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α](/preview/png/2116405.png)
چکیده انگلیسی
Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related with chemoresistance of solid tumors. The purpose of this study was to investigate the ability of noscapine to inhibit HIF-1α and sensitize ovarian cancer cells to cisplatin (DDP) under hypoxic conditions. Herein, we report that noscapine sensitized cobalt-induced chemoresistant ovarian cancer cells to DDP-induced apoptosis and inhibition of cell proliferation. Noscapine also promoted proteasome-mediated degradation of cobalt-stabilized HIF-1α protein, with subsequent inhibition of HIF-1 transcriptional activity. These data establish noscapine as a small molecule inhibitor of HIF-1α and provide an evidence for its combination with DDP in combating ovarian cancer chemoresistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 305, Issue 1, 1 June 2011, Pages 94–99
Journal: Cancer Letters - Volume 305, Issue 1, 1 June 2011, Pages 94–99
نویسندگان
Wenjing Su, Lei Huang, Qilin Ao, Qinghua Zhang, Xun Tian, Yong Fang, Yunping Lu,