کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116454 | 1084916 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage](/preview/png/2116454.png)
چکیده انگلیسی
Stress proteins protect cells against the effects of heat stress, such as cell death and DNA damage. We wished to determine if Annexin-1 (ANXA1) could mediate heat-induced growth arrest and DNA damage in MCF7 breast cancer cells. Heat induced a significant growth arrest at 4 h–24 h. Growth arrest and heat-induced DNA damage were significantly inhibited in MCF7 cells over-expressing ANXA1. These effects were associated with enhanced ERK activation and reduction in JNK phosphorylation. This study demonstrates that ANXA1, which we recently reported as a possible tumor suppressor gene, can protect cells from heat-induced growth arrest and DNA damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 294, Issue 1, 1 August 2010, Pages 111–117
Journal: Cancer Letters - Volume 294, Issue 1, 1 August 2010, Pages 111–117
نویسندگان
Sunitha Nair, M. Prakash Hande, Lina H.K. Lim,