کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2116807 1085034 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines
چکیده انگلیسی

We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detection of MK in the peripheral cells and precancerous lesions implies its potential for early cancer/tumor diagnosis. Furthermore, we have discovered two novel truncations of the MK, tMKB and tMKC, respectively, in the disease specimens. Our data not only provide an efficient methodology potentially for clinical application but also shed light on the molecular mechanism underlying the role for MK in tumorigenesis/carcinogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 253, Issue 1, 8 August 2007, Pages 60–67
نویسندگان
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