کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116846 | 1085039 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: A report from the Children’s Oncology Group
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: A report from the Children’s Oncology Group Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: A report from the Children’s Oncology Group](/preview/png/2116846.png)
چکیده انگلیسی
The long interspersed nucleotide element-1 (LINE-1) p40 protein was expressed in all 162 cases of childhood malignant germ cell tumor (MGCT) cells with weak, moderate, and strong immunoactivity in 43.8%, 37.7%, and 18.5%, respectively. Normal testicular tissue adjacent to tumors showed negative or weaker p40 expression than tumor cells. Multivariate analyses showed that strong expression of p40 was associated with poor differentiation, extragonadal site, and the histotype of yolk sac tumor. This study suggests that the active LINE-1 retrotransposon is a common event in pediatric MGCTs and abundant expression of p40 might play a role during the malignant transformation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 247, Issue 2, 18 March 2007, Pages 204–212
Journal: Cancer Letters - Volume 247, Issue 2, 18 March 2007, Pages 204–212
نویسندگان
Yinghao Su, Stella Davies, Mary Davis, Hua Lu, Roger Giller, Mark Krailo, Qiuyin Cai, Leslie Robison, Xiao-Ou Shu,