کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2116925 1085044 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of gastric GIST in rat and establishment of GIST cell line
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Induction of gastric GIST in rat and establishment of GIST cell line
چکیده انگلیسی

Continuous administration of the direct-reacting carcinogen N-methyl-N′-nitro-N-nitrosoguanidine reportedly produces not only adenocarcinoma in rats, but also mesenchymal tumors. A large number of tumors diagnosed as gastrointestinal smooth muscle tumors actually represent gastrointestinal stromal tumors (GISTs) in human cases. We have induced mesenchymal tumors by duodenal reflux in rats. To clarify the differentiation of these mesenchymal tumors, immunohistochemical investigations were undertaken. In addition, the first culture model of GIST-DR derived from GIST induced by duodenal reflux was established. GIST-DR cells, both in vitro and in vivo, were strongly immunopositive for both KIT and CD34, and STI571 (Imatinib mesylate) blocked the proliferation of this cell line. The present results suggest that duodenal reflux plays a role in the histogenesis of GIST.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 231, Issue 2, 18 January 2006, Pages 295–303
نویسندگان
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