کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2119464 | 1546802 | 2011 | 17 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: PPARγ: A molecular link between systemic metabolic disease and benign prostate hyperplasia PPARγ: A molecular link between systemic metabolic disease and benign prostate hyperplasia](/preview/png/2119464.png)
The emergent epidemic of metabolic syndrome and its complex list of sequelae mandate a more thorough understanding of benign prostatic hyperplasia and lower urinary tract symptoms (BPH/LUTS) in the context of systemic metabolic disease. Here we discuss the nature and origins of BPH, examine its role as a component of LUTS and review retrospective clinical studies that have drawn associations between BPH/LUTS and type II diabetes, inflammation and dyslipidemia. PPARγ signaling, which sits at the nexus of systemic metabolic disease and BPH/LUTS through its regulation of inflammation and insulin resistance, is proposed as a candidate for molecular manipulation in regard to BPH/LUTS. Finally, we introduce new cell and animal models that are being used to study the consequences of obesity, diabetes and inflammation on benign prostatic growth.
Journal: Differentiation - Volume 82, Issues 4–5, November–December 2011, Pages 220–236