کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2119466 1546802 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cholesterol and benign prostate disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Cholesterol and benign prostate disease
چکیده انگلیسی

The origins of benign prostatic diseases, such as benign prostatic hyperplasia (BPH) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), are poorly understood. Patients suffering from benign prostatic symptoms report a substantially reduced quality of life, and the relationship between benign prostate conditions and prostate cancer is uncertain. Epidemiologic data for BPH and CP/CPPS are limited, however an apparent association between BPH symptoms and cardiovascular disease (CVD) has been consistently reported. The prostate synthesizes and stores large amounts of cholesterol and prostate tissues may be particularly sensitive to perturbations in cholesterol metabolism. Hypercholesterolemia, a major risk factor for CVD, is also a risk factor for BPH. Animal model and clinical trial findings suggest that agents that inhibit cholesterol absorption from the intestine, such as the class of compounds known as polyene macrolides, can reduce prostate gland size and improve lower urinary tract symptoms (LUTS). Observational studies indicate that cholesterol-lowering drugs reduce the risk of aggressive prostate cancer, while prostate cancer cell growth and survival pathways depend in part on cholesterol-sensitive biochemical mechanisms. Here we review the evidence that cholesterol metabolism plays a role in the incidence of benign prostate disease and we highlight possible therapeutic approaches based on this concept.

Research highlights
► The prostate is a cholesterol sensitive organ.
► Hypercholesterolemia mediates inflammatory processes that may promote prostate disease.
► Cholesterol-lowering drugs reduce prostate cancer progression.
► Cholesterol-lowering drugs reduce benign prostate enlargement in animal models.
► Cholesterol-lowering approaches may improve BPH symptoms in human patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Differentiation - Volume 82, Issues 4–5, November–December 2011, Pages 244–252
نویسندگان
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