کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2119610 | 1085406 | 2012 | 9 صفحه PDF | دانلود رایگان |
Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) were originally discovered as growth factors for hematopoietic stem cells (HSCs). It has been well defined that SCF and G-CSF contribute to regulation of lineage commitment for HSCs. However, little is known about whether SCF and G-CSF play roles in the determination and differentiation of neural stem cells (NSCs). Here we demonstrate the novel function of SCF and G-CSF in controlling cell cycle and cell fate determination of NSCs. We also observe that SCF and G-CSF promote neuronal differentiation and inhibit astroglial differentiation at the early stage of differentiation. In addition, our research data reveal that SCF in combination with G-CSF has a dual function in promoting cell cycle exit and directing neuronal fate commitment at the stage of NSC dividing. This coordination effect of SCF+G-CSF on cell cycle arrest and neuronal differentiation is through enhancing neurogenin 1 (Ngn1) activity. These findings extend current knowledge regarding the role of SCF and G-CSF in the regulation of neurogenesis and provide insights into the contribution of hematopoietic growth factors to brain development and remodeling.
► Hematopoietic growth factors: Hematopoietic growth factors control neural stem cell proliferation and differentiation.
► Neural stem cells: SCF+G-CSF triggers neuronal fate switch during neural stem cell proliferation.
► Neurogenin 1: Neurogenin 1 is required for SCF+G-CSF-induced neuronal differentiation of neural stem cells.
Journal: Differentiation - Volume 83, Issue 1, January 2012, Pages 17–25