|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|2121316||1085776||2015||11 صفحه PDF||سفارش دهید||دانلود رایگان|
• 3-D neurovascular histology with cell tracing is used to study islet transplantation.
• Donor islet Schwann cells and pericytes participate in graft neurovascular regeneration.
• Islet graft microenvironment includes Schwann cell sheath and perivascular pericytes.
The primary cells that participate in islet transplantation are the endocrine cells. However, in the islet microenvironment, the endocrine cells are closely associated with the neurovascular tissues consisting of the Schwann cells and pericytes, which form sheaths/barriers at the islet exterior and interior borders. The two cell types have shown their plasticity in islet injury, but their roles in transplantation remain unclear. In this research, we applied 3-dimensional neurovascular histology with cell tracing to reveal the participation of Schwann cells and pericytes in mouse islet transplantation. Longitudinal studies of the grafts under the kidney capsule identify that the donor Schwann cells and pericytes re-associate with the engrafted islets at the peri-graft and perivascular domains, respectively, indicating their adaptability in transplantation. Based on the morphological proximity and cellular reactivity, we propose that the new islet microenvironment should include the peri-graft Schwann cell sheath and perivascular pericytes as an integral part of the new tissue.
Journal: EBioMedicine - Volume 2, Issue 2, February 2015, Pages 109–119