کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2121909 1547101 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relative mortality rates from incident chronic diseases among breast cancer survivors – A 14 year follow-up of five-year survivors diagnosed in Denmark between 1994 and 2007
ترجمه فارسی عنوان
میزان مرگ و میر نسبی از بیماری های مزمن حادثه ای در سرطان های سرطان سینه؟ یک پیگیری 14 ساله از بازماندگان پنج ساله بین سالهای 1994 تا 2007 در دانمارک تشخیص داده شد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

BackgroundIt remains unknown whether incident chronic diseases are more often fatal among breast cancer survivors than among women free of breast cancer.MethodsWe conducted a nationwide matched cohort study of all Danish breast cancer patients diagnosed between 1994 and 2007, who survived for five years. We compared their long-term mortality with five times as many women from the general population without breast cancer, matched on age. We used time-varying methods to compute mortality rate ratios (MRRs) for incident diseases included in the Charlson Comorbidity Index (CCI).ResultsOne third of five-year breast cancer survivors developed incident diseases during 14 years of follow-up, with about the same incidence as women without breast cancer. Mortality associated with any incident disease was similar among breast cancer survivors (MRR = 7.1, 95% confidence interval (CI): 6.7, 7.4) and comparison women (MRR = 7.5, 95% CI: 7.3, 7.7). Among breast cancer patients, relative mortality associated with incident diseases was higher among patients treated with chemotherapy (MRR = 10, 95% CI: 8.7, 12) and radiotherapy (MRR = 9.8, 95% CI: 8.8, 11) than among patients who received surgery (MRR = 7.0, 95% CI: 6.7, 7.4) or hormonal therapy (MRR = 6.3, 95% CI: 5.8, 6.9).ConclusionThere were no marked differences in mortality of diseases among breast cancer survivors and women from the general population. Among breast cancer patients, new diseases were more often fatal in patients treated with chemotherapy and radiotherapy. Five-year breast cancer survivors have similar risk of dying from new chronic medical conditions as women from the general population without breast cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 51, Issue 6, April 2015, Pages 767–775
نویسندگان
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