کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2121988 1547121 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prospective screening for ALK: Clinical features and outcome according to ALK status
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Prospective screening for ALK: Clinical features and outcome according to ALK status
چکیده انگلیسی

The aim of this study was to analyse the clinico-pathological characteristics and outcomes of a cohort of French patients who were prospectively screened for Anaplastic Lymphoma Kinase (ALK) rearrangement.One hundred and sixteen consecutive patients screened for ALK rearrangement to be recruited into a crizotinib registration trial were included from eight French centres. ALK rearrangement was detected by fluorescence in situ hybridization.Seventeen patients (14.6%) were positive for ALK. ALK+ patients were younger (p = 0.049) and more likely to be males (p = 0.032), non- or light-smokers (p = 0.048) and without underlying respiratory disease (p = 0.025) compared to ALK− patients. Thyroid-transcription factor-1 expression was present in all ALK+ tumours. ALK+ tumours tended to have lymph node and brain metastases. In multivariate analyses, gender, smoking history and N stage were independently associated with ALK status. Median overall survival (OS) was not reached for ALK+ patients and was significantly longer than for ALK− patients (hazard ratio for death for ALK− patients 2.98; 95% CI [1.29–6.90], p = 0.01).French ALK+ patients present a specific phenotype. ALK rearrangement should be determined to improve OS with an effective targeted therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 50, Issue 7, May 2014, Pages 1239–1246
نویسندگان
, , , , , , , , , , , ,