کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2123283 1547208 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High-dose methylprednisolone can induce remissions in patients with fludarabine-refractory chronic lymphocytic leukaemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
High-dose methylprednisolone can induce remissions in patients with fludarabine-refractory chronic lymphocytic leukaemia
چکیده انگلیسی

PurposeTo evaluate the clinical efficacy and safety of high-dose methylprednisolone (HDMP) in patients with fludarabine-refractory chronic lymphocytic leukaemia (CLL).MethodsTwelve patients who were refractory to fludarabine-based treatment were treated with 2–6 cycles of HDMP (1 g/m2 for 5 days).ResultsTen patients (83.3%) responded to treatment and three (25.0%) achieved a complete remission (CR). Two (16.7%) of which had no evidence of minimal residual disease (MRD) after treatment. Patients with leukaemia cells that have high expression of ZAP-70 or CD38, unmutated immunoglobulin heavy chain variable region (IGHV), mutated p53 or adverse cytogenetic features achieved response to treatment at rates that appeared similar to those achieved by patients who did not have such disease characteristics. With a median follow-up of 13 (4–30) months, the median overall survival (OS) and the progression-free survival (PFS) have not been achieved. Treatment with HDMP was well tolerated, notably in the patients having poor myeloid reserve and pretreated cytopaenias.ConclusionsHDMP is an effective non-myelotoxic regimen for the treatment of patients with fludarabine-refractory CLL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 46, Issue 12, August 2010, Pages 2145–2149
نویسندگان
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