کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2123347 1547214 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women
چکیده انگلیسی

Carotenoids have antioxidant and antiproliferative properties and may reduce the risk of breast cancer. We examined the association between dietary carotenoids and risk of invasive breast cancer in the Swedish Mammography Cohort, a population-based cohort of 36,664 women who completed a questionnaire in 1997. During a mean follow-up of 9.4 years, 1008 women were diagnosed with incident breast cancer. Dietary carotenoids were not significantly associated with the risk of breast cancer overall or with any subtype defined by oestrogen receptor (ER) and progesterone receptor (PR) status. However, dietary α-carotene and β-carotene were inversely associated with the risk of ER–PR-breast cancer among ever smokers. Among ever smokers, the multivariable relative risks of ER–PR-breast cancer comparing the highest with the lowest quintile of intake were 0.32 (95% confidence interval (CI): 0.11–0.94; Ptrend = 0.01) for α-carotene and 0.35 (95% CI: 0.12–0.99; Ptrend = 0.03) for β-carotene. The risk of breast cancer also decreased with increasing intakes of α-carotene (Ptrend = 0.02) and β-carotene (Ptrend = 0.01) among women who did not use dietary supplements. These findings suggest that dietary α-carotene and β-carotene are inversely associated with the risk of breast cancer among smokers and among women who do not use dietary supplements.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 46, Issue 6, April 2010, Pages 1079–1085
نویسندگان
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