کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2123648 1547164 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimisation of the size variation threshold for imaging evaluation of response in patients with platinum-refractory advanced transitional cell carcinoma of the urothelium treated with vinflunine
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Optimisation of the size variation threshold for imaging evaluation of response in patients with platinum-refractory advanced transitional cell carcinoma of the urothelium treated with vinflunine
چکیده انگلیسی

BackgroundVinflunine (VFL) has been approved in the European Union for second-line treatment of advanced transitional cell carcinoma of the urothelial tract (TCCU) in patients who progress after a platinum based regimen. However, very few patients achieve response by response evaluation criteria in solid tumours (RECIST). Therefore, another ‘response’ threshold may be more useful than RECIST 1.0 in this setting.MethodsOne hundred and seventy nine patients with advanced TCCU treated with second-line VFL therapy had chest Computed Tomography (CT) and abdominal/pelvic CT or MRI performed at baseline and at first follow-up (6 weeks ± 3 days) after therapy initiation. Tumour measurements and response by RECIST 1.0 were correlated with overall survival (OS). Kaplan–Meier and receiver operating characteristic (ROC) analysis were then used to determine the optimal size threshold to define ‘responders’. Impact of adverse prognostic factors including Eastern Cooperative Oncology Group Performance Status (ECOG PS) >0, Hb <10 g/dL, and liver metastases was analysed.ResultsTumour response included 13 partial responses (PR) by RECIST 1.0 and 52 patients with ⩾10% decrease in the sum of longest diameters. Responders by RECIST 1.0 did not have a statistically significant improvement in OS, while patients with sum long axis diameter (SLD) reduction of ⩾10% had a longer OS than those with SLD reduction of <10%: 11.3 versus 6.9 months (log rank p = 0.0224). ROC analysis yielded ⩾10% decrease in SLD as the optimal size change correlating with OS. These results persisted on multivariate analysis.ConclusionIn the study population, a ⩾10% reduction in SLD at first follow-up imaging is a better early predictor of outcome than RECIST.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 48, Issue 10, July 2012, Pages 1495–1502
نویسندگان
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