کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2123683 1547229 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AML
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Interleukin-2 receptor alpha-chain (CD25) expression on leukaemic blasts is predictive for outcome and level of residual disease in AML
چکیده انگلیسی

We investigated the role of CD25 as a prognostic marker in acute myeloid leukaemia (AML).Seventy-two newly diagnosed patients ⩽60 years were retrospectively analysed by flow cytometry for CD25 positivity of AML blasts.Patients with CD25 expression of >10%, when compared to ⩽10%, had a significantly shorter overall survival (OS, p = 0.0005) and relapse-free survival (RFS, p = 0.005). In multivariate analysis CD25 expression is an independent adverse factor for OS and RFS. High CD25 combined with FLT3-ITD positivity resulted in the poorest OS and RFS (p = 0.001 and p = 0.003, respectively). CD25 expression remained prognostic within the intermediate cytogenetic risk group. In addition, after the first cycle of chemotherapy, a significantly higher MRD frequency was found in patients expressing CD25 above cut-off (p = 0.003).Our results show that CD25 expression is an independent adverse prognostic marker in AML patients ⩽60 and correlates with MRD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 45, Issue 9, June 2009, Pages 1692–1699
نویسندگان
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