کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2124427 | 1547254 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: A dose-escalation study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: A dose-escalation study Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: A dose-escalation study](/preview/png/2124427.png)
چکیده انگلیسی
Three treatment cohorts were assessed, using different dosing regimens. A total of 24 women with MBC were enrolled sequentially. The regimen comprising erlotinib 100Â mg/day continuously, capecitabine 825Â mg/m2 bid on days 1 to 14 and docetaxel 75Â mg/m2 intravenously every 3 weeks on day 1 was well tolerated and was established as the MTD. Overall response rate was 67%, comprising two complete and 12 partial responders in 21 assessable patients. The most common treatment-related adverse events were gastrointestinal disorders and skin toxicities. Pharmacokinetic studies showed that exposure to the three drugs was not reduced when given in combination. These encouraging preliminary results warrant further trials of the combination in MBC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 44, Issue 3, February 2008, Pages 419-426
Journal: European Journal of Cancer - Volume 44, Issue 3, February 2008, Pages 419-426
نویسندگان
Chris Twelves, José M. Trigo, Rob Jones, Flavio De Rosa, Ashok Rakhit, Scott Fettner, Tonya Wright, José Baselga,