کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2124456 | 1547256 | 2008 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Here, we used quantitative real time RT-PCR to determine expression levels of TAp53, TAp73 and their N-terminal splice variants in a cohort of 169 ovarian cancer patients with stage I and stage III disease. The TAp73 levels in stage III biopsies differed by 100-fold depending on the p53 status and overall survival appears to be significantly related to ÎNp73 expression. Kaplan-Meyer analyses did not suggest a correlation between overall survival and levels of TAp73, ÎNp73 or the ÎNp73/TAp73 ratio. In conclusion, these data suggest that at least in our patient cohort p53 and p73 expression levels are not correlated to malignant progression of ovarian cancer. They might, however, play a role in tumour initiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 44, Issue 1, January 2008, Pages 131-141
Journal: European Journal of Cancer - Volume 44, Issue 1, January 2008, Pages 131-141
نویسندگان
Mirko Marabese, Sergio Marchini, Eleonora Marrazzo, Pietro Mariani, Dario Cattaneo, Roldano Fossati, Anna Compagnoni, Mauro Signorelli, Ute M. Moll, A. Maria Codegoni, Massimo Broggini,